Tottenham Hotspur & Chelsea meet in this weekend’s early match on Saturday, and Andre Villas-Boas will have revenge on his mind as the former employer travels to White Hart Lane.
Blues skipper John Terry starts the first of a four-match ban, whilst Jermain Defoe and Emmanuel Adebayor fight for one Spurs place up-front.
Michael Owen will hope for a happy return to Manchester United when his Stoke City side make the trip to Old Trafford, whilst Liverpool will be aiming to improve on their home form when Reading make the trip to Anfield.
Manchester City will be looking to get back in title contention with a win at West Brom, whilst Southampton travel to West Ham in a clash between two of last season’s promoted teams.
Norwich host Arsenal in the late kick-off, whilst Aston Villa travel to Fulham and Swansea City meet Wigan.
On Sunday, the Tyne-Wear derby sees Sunderland host Newcastle United, whilst Mark Hughes continues to fight for his job at QPR as they host a resurgent Everton.