Chelsea and Manchester United go head-to-head in a highly-anticipated clash between two of the Premier League's title contenders.
Roberto Di Matteo will be hoping for another excellent performance from Petr Cech, whilst Sir Alex Ferguson will opt for David de Gea with Anders Lindegaard still out through injury.
In defence, Chelsea will be without John Terry, who serves the second of his four-match suspension against the Red Devils. Chris Smalling is back in training, but unlikely to make the starting XI.
Frank Lampard is the major casualty for the Blues, picking up a calf injury in the Champions League defeat to Shaktar Donetsk in midweek. Shinji Kagawa is also out for the visitors with a knee problem.
Up-front, Fernando Torres will lead the line once again at Stamford Bridge, with Daniel Sturridge putting the Spaniard under serious pressure. For Manchester United, Ferguson has some big decisions to make, with Wayne Rooney, Robin Van Persie, Danny Welbeck and Javier Hernandez all pushing to start.
Chelsea predicted line-up v Manchester United:
Petr Cech; Branislav Ivanovic, Gary Cahill, David Luiz, Ashley Cole; John Obi-Mikel, Ramires; Eden Hazard, Oscar, Juan Mata; Fernando Torres.
Manchester United predicted line-up v Chelsea:
David de Gea; Rafael da Silva, Rio Ferdinand, Jonny Evans, Patrice Evra; Michael Carrick, Tom Cleverley, Paul Scholes; Danny Welbeck, Robin Van Persie, Wayne Rooney.