The last time Arsenal played at Old Trafford, Robin van Persie scored once and missed a penalty as the Gunners were humbled 8-2 against Manchester United.
Wayne Rooney scored a hat-trick that day, and also failed from the spot, and now he and Van Persie are both set to start for Manchester United as they welcome Arsenal on Saturday.
With both clubs wanting to dominate possession at Old Trafford, expect both managers to choose midfields with ball retention in mind.
Jack Wilshere is set to join Santi Cazorla and Mikel Arteta in the middle of the park for Arsenal, while Paul Scholes could return for Manchester United to dictate the game alongside Michael Carrick.
Do not be surprised to see Rooney start in a deeper role in order to help out in midfield, while a spot for Antonio Valencia will see United start with the same diamond which began against Stoke, and provides an outlet in place of Tom Cleverley.
Despite playing 120 minutes in the week against Chelsea, Javier Hernandez is in with a shot of partnering Van Persie for United, while they are set to be up against Per Mertesacker and Thomas Vermaelen in the centre of the Arsenal defence.
Arsene Wenger may have been tempted to push his captain out to left-back but injuries and fatigue should mean that the unpredictable Andre Santos gets a start.
Bacary Sagna made his comeback against Queens Park Rangers last week and is set to keep his place in the XI while, in attack, Theo Walcott could get the nod after his hat-trick against Reading.
Walcott also played 120 minutes, but will be riding high after his exploits at the Madjeski, while injuries to Alex Oxlade-Chamberlain and Gervinho leave Arsenal short in that department.
Manchester United: David de Gea; Rafael da Silva, Rio Ferdinand, Jonny Evans, Patrice Evra; Antonio Valencia, Michael Carrick, Paul Scholes; Wayne Rooney, Robin van Persie, Javier Hernandez.
Arsenal: Vito Mannone; Bacary Sagna, Per Mertesacker, Thomas Vermaelen, Andre Santos; Jack Wilshere, Mikel Arteta, Santi Cazorla; Theo Walcott; Oliver Giroud; Lukas Podolski.