Arsenal could go into their crucial Champions League clash against Schalke this week without Theo Walcott who is struggling with illness, while Aaron Ramsay has been ruled out of clash altogether by Arsene Wenger.
The Welsh midfielder picked up a groin strain during the Gunners 2-1 defeat against Manchester United at Old Trafford on Saturday and will miss the trip to Germany.
Swiss defender Johan Djourou will take the midfielder’s place on the plane, while the only other change to Wenger’s squad comes as James Shea replaces the ineligible Damian Martinez.
Wenger could also be without Walcott, who was a substitute for the defeat against United, after the winger fell ill last night.
The England international will still travel with the Gunners to the Veltins-Arena but faces a race against time if he is to be fit to start.
Arsenal go into the game needing to win in order to regain control over Group B after their 2-0 defeat against the Bundesliga outfit at the Emirates Stadium two weeks ago.
Having started off their campaign with back-to-back wins against Montpellier and Olympiakos, the Gunners appeared on course for a comfortable qualification to the knockout stages.
However goals from Klaas-Jan Huntelaar and Ibrahim Afellay consigned them to defeat and second place in the group, one point behind their German rivals.
The possible absence of Walcott adds to a growing injury list for Wenger, who is unable to call upon Gervinho, Kieran Gibbs, Tomas Rosicky, Abou Diaby, Alex Oxlade-Chamberlain and Wojciech Szczesny for the game on Tuesday.