Arsenal and Tottenham Hotspur open the Premier League weekend with a highly anticipated North London derby at the Emirates Stadium.
The two sides sit seventh and sixth in the table respectively, and both need a victory to push towards the Champions League qualification places.
Liverpool host Wigan Athletic at Anfield, with Luis Suarez set to lead the line for the Reds despite speculation linking the Uruguayan international with a move to Manchester City.
Roberto Mancini’s side are also in action at 3 o’clock, hosting Aston Villa at the Etihad Stadium as they look to move to the top of the Premier League table.
Chelsea and Everton, third and fourth respectively, travel to West Bromwich Albion and Albion and Reading, whilst QPR and Southampton meet in a battle of the basement boys at Loftus Road.
Swansea travel to Newcastle, whilst Norwich City host Manchester United in the late kick-off at Carrow Road. Wayne Rooney is an injury doubt, but Robin Van Persie should be fit for the Red Devils.
In the only clash on Sunday, Fulham host Sunderland at Craven Cottage, with Martin O’Neill’s side desperate to move away from the relegation zone.