The United defender has been on the sidelines since late September after undergoing a meniscus operation on the same troublesome knee that kept him out of action for most of last season.
Vidic came back for United's first match of the season, a 1-0 defeat to Everton at Goodison Park, but a recurrence of the knee problem led to surgery.
The Serbian international has impressed the Manchester United medical staff with his recovery, and the 31-year-old is yet to experience any problems or setbacks since he returned to full first-team training.
Sir Alex Ferguson initially expected Vidic to return around Christmas, but the Manchester United boss confirmed today that he could make his comeback as early as Wednesday against Cluj in the Champions League.
The Old Trafford club have already secured their passage into the last-16 of Europe's elite club competition, and their match against the Romanian side is their final group stage fixture.
Manchester United squeaked past West Ham on Wednesday evening - a first minute Robin Van Persie goal was enough to take the Red Devils back to the summit of the Premier League table.
But United have struggled to keep clean sheets in the absence of Vidic - their 1-0 victory over the Hammers was only their fourth of the campaign.