Reading v Manchester United; Barclays Premier League; Majdeski Stadium; 17:30 kick-off.
Jimmy Kebe is the biggest concern for the hosts, and is again a doubt for Brian McDermott after missing three weeks with a groin injury.
Alex McCarthy and Jem Karacan are also out for the Royals, although midfielder Danny Guthrie is back in contention after recovering from a thigh strain.
For the visitors, Sir Alex Ferguson will again be without wingers Antonio Valencia and Nani with hamstring and hip injuries respectively.
Veterans Paul Scholes and Ryan Giggs are both available for selection, although Nemanja Vidic misses out again despite a quicker recover from his serious knee injury.
Ferguson wary of Reading threat
Sir Alex Ferguson has warned his players that they face another tricky away day at Reading this weekend.
The Red Devils were stung at Norwich a fortnight ago, when Anthony Pilkington’s header ensured a surprise 1-0 win for the Canaries at Carrow Road.
Ferguson believes that trips to the lower and mid-table teams in the English top flight are getting harder, and Brian McDermott’s side will make things difficult in Berkshire tomorrow evening.
“Away games are getting more difficult. Norwich was a good example of that. They fought like tigers and were really motivated. It was a difficult day for us,” Ferguson told his pre-match press conference, according to The Daily Mail.
“We expect another difficult game like Norwich tomorrow. The job Brian McDermott has done there is excellent. It took him a little bit of time to get his ideas across but in the second half of last season came from nowhere to win the league.”
The United boss was also reticent to dismiss Chelsea’s challenge for the Premier League title, despite the Blues stuttering to back-to-back 0-0 draws under new manager Rafael Benitez.
Despite the Stamford Bridge outfit falling seven-points behind at the top of the table, Ferguson insists it’s far from a two-horse race at this stage of the campaign.
“It's coming to the end of November and I don't think you can be certain of saying it's going to be a two-horse race at this time. Over the years we've always hoped that the top five or six are all capable of winning the league but eventually it ends up a two-horse race. It's been like that for years, and last season there was big gap between ourselves and City,” added Ferguson.
“The important thing is to look at yourselves. You want to stay up there every time and it's not an easy league to do that.”