Mark Noble will return for West Ham after serving his suspension during the mid-week defeat against Manchester United, which will result on James Tomkins dropping back into the centre of defence.
James Collins is likely to make way for the Team GB defender, while George McCartney should have recovered in time to replace Guy Demel at left-back.
Other than this, the Hammers are unlikely to be unchanged in midfield and attack with Kevin Nolan continuing to feed off Andy Carroll, provided the latter can overcome a knock he sustained at Old Trafford.
Cesar Azpilicueta has performed impressively for Chelsea of late, but the Spaniard is likely to make way for a taller teammate as Rafa Benitez looks to negate West Ham's aerial threat.
This should see Branislav Ivanovic move outside to right-back, while Gary Cahill comes in alongside David Luiz, although Ashley Cole is expected to retain his place on the left.
Oriol Romeu played well enough against Fulham to keep his spot ahead of John Obi Mikel, while Juan Mata comes into the team in place of Ryan Bertrand.
Oscar and Eden Hazard look set to continue behind lone striker Fernando Torres, who will also have plenty of defensive work to at set-pieces.
West Ham: Jussi Jaaskelainen; Joey O'Brien, Winston Reid, James Tomkins, George McCartney; Mark Noble, Mo Diame, Matt Taylor, Matt Jarvis, Kevin Nolan; Andy Carroll.
Chelsea: Petr Cech; Branislav Ivanovic, Gary Cahill, David Luiz, Ashley Cole; Oriol Romeu, Ramires, Oscar, Juan Mata, Eden Hazard; Fernando Torres.