Manchester United v CFR Cluj; UEFA Champions League Group H; Old Trafford; 05/12/12.
Sir Alex Ferguson has confirmed that Nemanja Vidic is not yet fit to return to first team action, meaning Phil Jones, Chris Smalling and Alex Buttner are all likely to start in defence.
Antonio Valencia remains out of action through injury, but striker Wayne Rooney will play despite qualification already being assured.
For the Romanian visitors, manager Paulo Sergio has the vast majority of his squad available for selection, with Ronny and Bakary Sare the only long-term absentees.
Ferguson: Rooney needs games ahead of Manchester derby
Manchester United manager Sir Alex Ferguson is expected to shuffle his pack for the clash against CFR Cluj, but one first team regular who won’t be getting a rest is striker Wayne Rooney.
The England international scored twice against Reading in the 4-3 Premier League win on Saturday, but will keep his place in the side as the manager looks to get the very best out of last season’s top scorer for the Red Devils.
"When Wayne gets interrupted he needs three games to get back. That's why he'll definitely play tomorrow. Wayne needs to play a lot of games to get his match-fitness up,” Ferguson told his pre-match press conference.
“He's a strongly-built lad and when he misses two games, it takes him three games to come back. It's the way he's always been. He'll play tomorrow night and hopefully that brings him on further. On Saturday [at Reading], that was his best performance of the season so far."
United have already secured qualification as winners of the group, but Cluj will be desperate to get a positive result to keep alive their hopes of progressing to the last 16.
Paulo Sergio’s side need to better Galatasaray’s result in Braga to finish in second, and the manager hopes it just might be their day at Old Trafford.
"We always prepare by thinking we can take something from the game – this game is no different. Of course, everybody recognises the quality of Manchester United and what they have done over the years, but who knows if tomorrow will be our day or not,” he told his pre-match press conference.
“We know that in football everything is possible, and I'm sure if we played 10 or 15 games here we'd win one; hopefully that'll come tomorrow, but you never know."