Sir Alex Ferguson will be able to call on his big guns once more after resting the likes of Wayne Rooney and Robin van Persie for Manchester United's mid-week defeat against Galatasaray.
Rooney has trained all week, despite being hit by tonsillitis, and is available for selection while Van Persie will be refreshed having not been required to travel to Istanbul.
Danny Welbeck and Javier Hernandez both started in mid-week, but both are expected to be replaced by Ferguson's first-choice front duo.
Jonny Evans is a doubt but Chris Smalling returns, and the latter is likely to feature alongside Rio Ferdinand, despite Phil Jones his long-awaited Manchester United return in Wednesday's Champions League outings.
Alex Buttner was given the nod at left-back in Turkey but is set to be replaced by Patrice Evra, who was also rested, and Nick Powell is likely to drop to the bench, despite impressing against Galatasaray.
Anderson and Darren Fletcher also started, but Ferguson is expected to switch back to a regular 4-4-2 with Antonio Valencia and Ashley Young on the flanks, with Nani still unavailable.
Mark Bowen and Eddie Niedzwiecki will take charge of Queens Park Rangers for the trip to Old Trafford following the dismissal of Mark Hughes on Friday.
Harry Redknapp will be waiting in the wings to take over, although may have little to do with the team selection this weekend.
Stephane Mbia returns from suspension and looks set to take his place in the starting XI, while Jose Bosingwa will keep his place at full-back with Fabio ineligible to play against his parent club.
Park Ji-Sung is unlikely to be fit to face Manchester United for the first time since leaving in the summer, while Bobby Zamora is unavailable after having surgery on an injured hip.
Manchester United: Anders Lindegaard; Rafael, Chris Smalling, Phil Jones, Patrice Evra; Antonio Valencia, Michael Carrick, Tom Cleverley, Ashley Young; Robin van Persie, Wayne Rooney,
Queens Park Rangers: Julio Cesar; Armand Traore, Anton Ferdinand, Jose Bosingwa; Stephane Mbia, Esteban Granero, Alejandro Faurlin, Adel Taarabt; Djibril Cisse, Junior Hoilett.