Andre Villas-Boas could recall Gareth Bale for the visit of Stoke after the Wales winger recovered from a hamstring injury sustained during Tottenham's victory over Fulham earlier this month.
The Spurs boss could also bring Michael Dawson back into the team, while Emmanuel Adebayor faces a late fitness test. Midfielder Scott Parker and left-back Benoit Assou-Ekotto will likely take their place on the bench after resuming first-team training.
Parker made his first appearance of the season last weekend in the Tottenham victory over Swansea, and the England international could make a starting return to the team on Saturday, but Villas-Boas will probably ease him back into action.
The former-West Ham star has been out of action since injuring his achilles during England's Euro 2012 campaign, and Tottenham will be delighted to see their reigning Player of the Season return as they aim for a Champions League qualification place.
Tottenham are in good form, having won four of their last five Premier League matches, and Stoke have found it difficult on their travels this term.
Here's your GMF predicted line-up for the match…
Lloris, Walker, Naughton, Caulker, Gallas, Sandro, Dembele, Lennon, Bale, Dempsey, Defoe