Manchester United will hope to build on their seven-point lead at the top of the Premier League table when they host high-flying West Brom at Old Trafford on Saturday.
The Red Devils have won all but one of their last seven league games and will be keen to maintain that run against the Baggies, who have been one of the surprise packages of the season so far.
Manchester City fans hit the road towards Norwich, for their second lengthy trek of the festive season, in the hope of seeing an improvement on the performance that saw their side slip to defeat at Sunderland.
Roberto Mancini may juggle his options once again to come up with his strongest possible eleven with so much at stake, as City look to close the gap on United.
Arsenal's players will be well-rested after their scheduled Boxing Day clash with West Ham was called off due to a planned London Underground strike.
Ahead of that postponement, Arsene Wenger's side had won their last three games on the bounce, and will be looking to climb as high as third with victory over Newcastle this weekend.
Tottenham are aiming to maintain their much-coveted place in the top four when they travel to the Stadium of Light.
Andre Villas-Boas' men eased past hapless Aston Villa in a comfortable 4-0 away victory on Wednesday, but travel to Wearside to face a Sunderland side which has started to show signs of improvement during an encouraging December.
Rafa Benitez will be reunited with old rivals Everton when Chelsea visit Goodison Park on Sunday.
The interim Blues boss knows all about David Moyes' side from his days as manager of Liverpool, and is unlikely to receive a warm reception on his return to Merseyside.
Elsewhere, Southampton travel to Stoke City, while Reading host West Ham at the Madejski Stadium.
Queens Park Rangers will be looking for only their second win of the season when they welcome Liverpool to Loftus Road, while fellow strugglers Aston Villa and Wigan Athletic lock horns in the Midlands.
Finally, Fulham entertain Swansea at Craven Cottage, with both teams looking to get back to winning ways.