Manchester United and Liverpool meet in a massive Premier League match-up at the weekend.

The Red Devils won their last outing 2-1 back in September, and will be confident of repeating the trick at Old Trafford on Sunday.

Sir Alex Ferguson appears to have settled on David De Gea as his No.1, and the Spaniard can expect to be in the sticks once again for the visit of the Reds.

Compatriot Pepe Reina will get the nod from Brendan Rodgers at the opposite end, in two of the easier decisions for the managers.

In defence, Manchester United have a couple of decisions to make, and despite a run of red cards in the fixture, Nemanja Vidic will expect to feature. Jonny Evans could get the nod ahead of Rio Ferdinand, with Rafael and Patrice Evra on the flanks.

For Liverpool, it’s a simple choice with Glen Johnson, Martin Skrtel and Daniel Agger in the side, and Andre Wisdom could come into the side to add more defensive cover ahead of Stewart Downing.

Anderson and Nani are both back in contention for the hosts, but are unlikely to start. Antonio Valencia should start on the right flank, with Michael Carrick and Paul Scholes in the centre. Ashley Young will hope he gets the nod over Ryan Giggs on the left.

For the Reds, captain Steven Gerrard can expect Lucas Leiva and Joe Allen for company in a 4-3-3 formation.

Up-front, the choice is simple for Manchester United, with Robin Van Persie and Javier Hernandez in great form. Danny Welbeck will be available from the bench, with Wayne Rooney still out through injury.

Liverpool will have Luis Suarez leading the line, with Raheem Sterling in support on the right and Daniel Sturridge set to make his Premier League debut on the left.

Manchester United predicted line-up v Liverpool:

David De Gea; Rafael, Nemanja Vidic, Jonny Evans, Patrice Evra; Antonio Valencia, Michael Carrick, Paul Scholes, Ashley Young; Robin Van Persie, Javier Hernandez.

Liverpool predicted line-up v Manchester United:

Pepe Reina; Andre Wisdom, Martin Skrtel, Daniel Agger, Glen Johnson; Joe Allen, Steven Gerrard, Joe Allen; Raheem Sterling, Luis Suarez, Daniel Agger.

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