Manchester United will be looking to capitalise on title rivals Manchester City's failure to beat basement boys Queens Park Rangers at Loftus Road last night, when they welcome Southampton to Old Trafford on Wednesday evening.
The Premier League leaders will be looking to maintain their impressive home record, which has delivered nine wins out of ten games on their own patch this season, scoring 30 goals along the way.
Robin van Persie is set to lead a host of big names back into Sir Alex Ferguson's starting line-up, after a number of first-team regulars were rested for last weekend's FA Cup victory over Fulham.
Club captain Nemanja Vidic and Rio Ferdinand are likely to be restored to the centre of defence, but the Red Devils boss will face a selection headache up front, after Javier Hernandez scored twice again on Saturday to stake his claim for inclusion from the start.
Ashley Young (knee) and Jonny Evans (hamstring) remain sidelined but Manchester United have no other injury concerns going into tonight's game.
Southampton meanwhile, could welcome back crocked captain Adam Lallana for new manager Mauricio Pochettino's second game in charge of the Saints, in what could prove to be a baptism of fire for the Argentine.
January signing Vegard Forren is in line to make his debut, but the south coast side will be without Jose Fonte and Guly do Prado, with both players sidelined by respective knee injuries.
Predicted Manchester United starting XI:
De Gea; Rafael, Ferdinand, Vidic, Evra; Carrick, Cleverley Scholes; Valencia, Rooney, Van Persie.
Predicted Southampton starting XI:
Boruc; Clyne, Yoshida, Forren, Shaw; Schneiderlin, Cork; Puncheon, Ramirez, Lallana; Lambert.