Manchester United will travel to Fulham looking for a repeat of their 4-1 win against the Cottagers in the FA Cup last weekend.
Whilst that match was at Old Trafford, the Red Devils will once again start as favourites, and could move ten-points clear at the top of the Premier League with a win in west London.
Sir Alex Ferguson appears settled with David de Gea as his No.1, and the Spaniard will expect to keep goal at Craven Cottage.
In defence, Rafael and Patrice Evra have been impressive this season in the full-back positions, whilst Rio Ferdinand and Nemanja Vidic are the senior choices at centre back in the absence of Jonny Evans through injury.
Midfield provides the biggest selection headache for Ferguson, with plenty of options available to the Manchester United manager.
Antonio Valencia provides defensive cover on the right hand side whilst being a danger going forward, and Shinji Kagawa is pushing for a start after impressing against Southampton in midweek.
Michael Carrick is enjoying the best season of his career in the centre of the park, and Ryan Giggs could provide some additional experience away from home.
Up-front, Ferguson has the luxury of leaving Javier Hernandez on the bench, with Wayne Rooney and Robin Van Persie the obvious starters for Manchester United.
Manchester United predicted line-up v Fulham:
David de Gea; Rafael, Nemanja Vidic, Rio Ferdinand, Patrice Evra; Antonio Valencia, Michael Carrick, Shinji Kagawa, Ryan Giggs; Robin Van Persie, Wayne Rooney.