Tottenham Hotspur and Newcastle United kick-off the weekend’s action in an intriguing match-up at White Hart Lane, with both sides chasing victory for differing reason.
Spurs can keep the pressure on the top clubs with a win, whilst a resurgent Toon know three points will move them well clear of the bottom three.
Chelsea host Wigan in the pick of the three o’clock matches, although the Blues’ title ambitions are almost over following defeat last weekend.
Arsenal travel to Sunderland and Stoke City host Reading, whilst Norwich meet Fulham at Carrow Road and QPR travel to Swansea.
The late fixture sees struggling Southampton host champions Manchester City, and anything other than three points would be a surprise for Roberto Mancini’s side.
Aston Villa host West Ham in Sunday’s early clash, before Everton travel to Old Trafford looking to go one better than last season’s draw.
Manchester United will want to avoid a result similar to that 4-4 encounter, which led to the downfall of their title challenge last season.
Then, on Monday night, Liverpool host West Bromwich Albion in a fixture that brings the weekend's action to a close.