Defending champions Atletico Madrid made a shock exit from the Europa League, crashing out of Europe's second tier club competition at the last-32 stage, despite recording a 1-0 away victory over Rubin Kazan last night.
Radamel Falcao's 84th minute goal at the Luzhniki Stadium in Moscow gave Diego Simeone's side a brief glimmer of hope of overturning the 2-0 deficit from last week's first leg defeat in the Spanish capital, but their Russian opponents held on to progress to the next round.
Rubin Kazan will now face another La Liga side in Levante, after their convincing 4-0 aggregate victory over Olympiakos. Obafemi Martins scored the only goal of the game in their 1-0 win in Greece last night.
Tottenham Hotspur were the first of three participating Premier League sides to safely navigate their way through to the last-16, after a late Mousa Dembele goal clinched a 1-1 draw with Lyon in France, to secure a 3-2 aggregate victory over their Ligue 1 counterparts.
Spurs' reward sees them meet Inter Milan in the next round, in a repeat of the Champions League last-16 clash in 2010/11, when Gareth Bale stole the show in the San Siro with a stunning hat-trick.
The Serie 'A' giants will not be an easy match for Andre Villas-Boas's men, though, after their emphatic 5-0 aggregate win over Romanian side CFR Cluj. Fredy Guarin scored twice and Marco Benassi added a late third as the Italians comfortably added to their 2-0 lead from the first leg.
Meanwhile, a Shola Ameobi penalty was enough to ensure Newcastle United prevailed, following the Magpies' 1-0 away victory over Metalist Kharkiv in Ukraine, in what was a relatively subdued affair after the goalless draw that preceded at St James' Park last Thursday.
Newcastle now meet Anzhi Makhachkala, who went through despite losing 1-0 to Hannover last night. The Russian side held a 3-1 advantage from the first leg, and squeezed through in spite of Sergio Pinto's 70th-minute strike in Germany.
Eden Hazard came off the bench for Chelsea to spare Rafa Benitez's blushes, and score a stoppage time equaliser against Sparta Prague at Stamford Bridge, securing a 1-1 draw and 2-1 aggregate victory, after Oscar's late goal in the Czech Republic last week.
The Blues now face Steaua Bucharest after they sent Ajax crashing out on penalties in what was the first ever shoot-out in the competition in its current format.
The Dutch giants held a 2-0 lead from the first leg in Amsterdam, but goals from Iasmin Latovlevici and Vlad Chiriches forced extra-time in Romania. With the two teams unable to be separated after another 30 minutes play, Latovlevici scored the decisive penalty after Lasse Schone and Niklas Moisander had missed for Ajax.
Liverpool were the only Premier League casualty at the last-32 stage, after they were knocked out by Zenit St Petersburg, despite recording an impressive 3-1 victory at Anfield on Thursday evening.
Two goals from Luis Suarez either side of a rare Joe Allen goal was the perfect response to Hulk's opener for the visitors, after the Brazilian striker capitalised on an error from Jamie Carragher.
However, the Reds' failure to score in the 2-0 loss in Russia last week saw them eliminated, with Zenit progressing on away goals. They now face FC Basel, who won 3-1 on aggregate against Dnipro Dnipropetrovsk.
Stuttgart eased into the last 16 with a 2-0 victory at Genk. With the tie delicately poised at 1-1 after the first leg in Germany, goals from Arthur Boka and Christian Gentner saw the Bundesliga side through.
They now face Lazio, who progressed following their 5-3 aggregate win over Borussia Monchengladbach. After drawing 3-3 in Germany, the Serie 'A' side needed a 2-0 victory at Stadio Olimpico, with goals from Antonio Candreva and Alvaro Gonzalez securing the Rome club's place in the next round.
The remaining last-16 ties sees Viktoria Plzen take on Fenerbache, and Benfica versus Bordeaux, after each club's aggregate victories over Napoli, Bate Borisov, Bayer Leverkusen and Dynamo Kiev.
After another exciting night of European action, GiveMeFootball brings you five of the best Europa League goals of the week!
What was your favourite goal? Leave a comment below, and add any of your own nominations that you think deserve to be included in the top five!