Nani, Anderson, Darren Fletcher and Paul Scholes all could be heading into their final few months as Manchester United players, as the report claims Sir Alex Ferguson is planning a summer shake-up of his Premier League-leading squad.
Nani and Anderson, both expensive additions following the 2006/07 season, could be shipped out at the end of the campaign, while Darren Fletcher and Paul Scholes wrestle with concerns over fitness and retirement respectively.
Fletcher is fighting a chronic bowel illness after he underwent surgery in December. The Manchester Evening News suggests Fletcher is targeting a return to the United squad next season, but it remains to be seen whether that can be achieved.
Scholes has also just returned to training following a two month injury layoff. The 38-year-old has not yet followed Ryan Giggs in signing a new United deal, and this season could be his last at Old Trafford.
For Nani and Anderson, the future depends on Ferguson's willingness to sell.
Neither has been first-choice this season and both have battled injury problems. Nani has been linked with an Old Trafford exit for much of the current campaign, although he returned to the squad for the recent Champions League second-leg against Real Madrid after an impressive goalscoring outing against Reading in the FA Cup.
The Madrid match ended with a red card for the Portuguese winger, and the 26-year-old now faces another spell on the sidelines with a hamstring problem.
Brazilian midfielder Anderson was an expensive teenage addition in the summer of 2007. He remains a hugely talented player, but cannot stay healthy.
Reports over the weekend in the Daily Mail had claimed Ferguson could be willing to offload a number of other players at the end of the season, including Alexander Buttner, Anders Lindegaard and Javier Hernandez.