1. Cristiano Ronaldo - 0.43 goals per game
It's rare that you'll find a list that the Real Madrid star doesn't come out on top of, and his scintillating form for Manchester United earns Cristiano Ronaldo his place atop the pile of Premier League's most lethal midfield marksmen.
84 goals in 196 appearances for the Red Devils hands him the very best goals per games ratio. The only argument is whether or not the Portuguese international should be regarded as a midfielder. There's no denying he now operates much more as a forward, but during his playing days at Old Trafford, he certainly fits the bill!