Ramos looks certain to reach three figures this Friday when Spain take on Finland and then go one better on the following Tuesday when La Roja take on France in a crucial World Cup qualifying double-header.
If he features in one of the two games, Ramos will become the eighth player to play for Spain 100 times, joining a fast growing group including five current Spanish internationals - Iker Casillas, Xavi, Xabi Alonso, Fernando Torres and Carlos Puyol - and admits it will be a proud moment for him.
The 26-year-old told AS: "It will be something to enjoy on a personal level. I hope I can enter into the history books of Spanish football. For me it's something to be proud of and a very big personal challenge.
"I've been in the national team for a long time and I'm proud of that. Hopefully I can say in the future that I've played many more games than 100."
Ramos was keen to emphasise the importance of both upcoming fixtures and not just the France match, who are level on points in Group I with Spain.
"We're very aware that they are two games that have a lot riding on them, we are playing to get through to the World Cup and we want to do things well,"he added.
"We can't underestimate anyone because these days any national team can hurt you. After that we will think about France."