France v Spain; World Cup qualifier Group I, Stade de France; Tuesday, 26th March; 20:00 KO.
Despite impressive performances by Raphael Varane and Paul Pogba against Georgia, they could both miss out for France as manager Didier Deschamps looks for experience.
Karim Benzema could also make way after yet another disappointing display in-front of goal on Friday.
Spain will be without left-back Jordi Alba after he picked up leg injury, with Arsenal's Nacho Monreal expected to take his place.
Juan Mata may also come into the team after only being used as a substitute in Friday's shock draw at home to Finland.
Del Bosque hits back amidst Spanish doubts
Spain manager Vicente del Bosque has claimed his side are not feeling the pressure ahead of tonight's crucial World Cup qualifier in Paris.
Following the draw against Finland in Madrid on Friday, the world and European champions have had doubts cast over them on whether they are still the best in the world.
However, Del Bosque, firmly believes that tonight's game will be more suited to Spain's style of play and that they can't let the pressure affect them.
"We are not anxious at all," he said, according to Goal.com.
"It is logical to reflect after what has happened in our last two games. Despite dominating completely we couldn't score more than once, so it is understandable that people will have doubts.
"We must stay calm, open up the pitch and use the width. We do need to find solutions, but this will be a more open game."
Spain are currently two points behind Les Blues, and with France left to play Finland, Georgia and Belarus, only victory will be enough if Spain want to finish top of the group.
The Spain boss was also quick to praise Didier Deschamps' side, and knows it will be a big challenge for his team if they are to come away from Paris with three precious points.
"France have players with pace and the ambition to play football," he added.
"There are talented players such as Benzema, Ribery, Cabaye and Valbuena.
"When the draw was made we knew France would be very difficult opponents for us. They have quality, experience and know how to play games like these."