England will need to improve on the second day of the Hong Kong Sevens, after suffering a defeat against the team they beat in Wellington in February.
Samoa took a 21-0 lead into half-time with two tries from Faatoina Autagavaia an one from Reupena Lavasa.
Sam Edgerley got a consolation score for England late on after Tulolo Tulolo added a fourth try for Samoa midway through the second half.
England have a double-header of Scotland and Portugal tomorrow, the latter winning the opening match between the two 27-21.
Wales narrowly defeated Australia in their opening with a late try from Cardiff Blues centre Cory Allen proving the winning score as the opening game in Pool A finished 19-14.
The shock of the day came in the other match from that group as Argentina drubbed South Africa 21-0.
New Zealand cruised to a 33-12 victory in Pool B over France, despite having World Player of the Year Tomasi Cama out through injury.