Napoli face AC Milan on Sunday in the pick of the Serie 'A' matches, with the Naples side sitting just a place and four points ahead of the Rossoneri in second.
Both sides are unlikely to catch leaders Juventus, but the runners-up spot remains up-for-grabs.
On Monday night Lazio play Juve after the Rome side were eliminated from the Europa League on Thursday, losing 3-1 on aggregate to Fenerbache.
Lazio are currently fifth but could move up to fourth if Fiorentina fail to win.
Sunday also see's sixth-placed Inter Milan travel to Sardinia to face 11th-placed Cagliari, and Marco Tardelli's side have won just one league match in their last four as a Europa League finish begins to slip away.
Sitting just below Inter are Roma, who travel to Turin to face Torino in the Stadio Olympico. A win for Roma could take them above Inter should the Milan outfit fail to win. Torino sit in 15th but could rise four places if they win and results go their way.
Palermo will be looking to move out of the bottom three when they face Bologna at the Renzo Barbera stadium.
The Sicilian outfit can move up to 17th with a win but an eight-point gap currently separates the bottom four from the rest.
The rest of Sunday's games includes Chievo v Catania and Genoa v Sampdoria.
Saturday's two fixtures see's bottom side Pescara host fellow-strugglers Siena, whilst fourth-placed Fiorentina travel to Atalanta.