Leicester City host Birmingham City at the King Power Stadium tonight, with the home side sitting just two points off the play-off places with five games to go.
Birmingham still have an outside chance of making the play-offs, but for all intent and purpose will probably miss out.
Nigel Pearson's men are currently in seventh-place behind Brighton & Hove Albion and Gus Poyet's men face the long trip up to Middlesbrough on Saturday hoping to gain three vital points to solidify their place in the top six.
Boro themselves are just seven points off Brighton and will know a win for them is just as crucial.
The 12.30 kick-off on Saturday see's newly-appointed Leeds United manager Brian McDermott make his debut on the touchline in the Yorkshire derby against Dave Jones' Sheffield Wednesday.
Neither club are safe from relegation so a win for either side will be a huge positive, and McDermott will undoubtedly be wishing for his bow to go as smoothly as possible.
Blackburn Rovers face Derby County at Ewood Park desperately needing three points to move out of the bottom three.
It's been a terrible season for Rovers fans as the club have sacked three mangers over the course of the campaign and relegation to Npower League 1 would destroy what little support there is for the Venky owners and cap a demoralising two seasons at Ewood Park.
Wolves play Huddersfield at Molineux in a six-pointer as the sides sit 20th and 21st respectively, and a win for either side could lift them to 18th.
After Cardiff City failed to finish-off Barnsley in midweek, the Bluebirds play Nottingham Forest in the Welsh capital looking to increase their lead at the top and all-but secure automatic promotion.
Billy Davis, in his second stint at the City Ground, will know the importance of three points as his side are currently fifth but are only three points away from falling out of the play-off places.
The rest of Saturday's Championship fixtures are Barnsley v Charlton, Blackpool v Burnley, Bristol City v Bolton, Ipswich v Hull and Peterborough v Watford.