Olivier Giroud's red card against Fulham was unfortunate, but ultimately a clumsy challenge meaning he will be absent for Arsenal in their next three Premier League games.
The Gunners have few options for the striker position - Walcott impressed as a striker around mid-season, while Podolski, who has recently been on the bench, has started just one game there against Sunderland on his debut.
Arsene Wenger did not complain in his post-match interview, merely saying that he slipped but he did not completely see it. The Arsenal boss implied that he is unlikely to appeal against it, which would leave him with a tough decision.
Podolski may seem the more natural fit against Manchester United. He might not quite have the physical presence of Giroud, but he is still 6ft and is a quick and powerful player with his rocket of a left foot.
However, Walcott's pace is at times devastating, despite his recent goal drought, he is still the club's top scorer. He can burst his way through a defence, and his clinical finishing has often been compared to Thierry Henry, while his assist tally has also been impressive.
Both Giroud and Walcott struggled against Fulham, but the likely potential line-ups could be:
Podolski - Walcott - Oxlade-Chamberlain
Oxlade-Chamberlain - Podolski - Walcott
Gervinho - Podolski - Walcott
Podolski - Walcott - Gervinho
Might this even mean an unlikely return to the bench for outcast Andrey Arshavin?
The Russian could make his final appearances for the Gunners as the season comes to a close. Only time will tell.
DISCLAIMER: This article has been written by a member of the GiveMeFootball Writing Academy and does not represent the views of GiveMeFootball.com or SportsNewMedia. The views and opinions expressed are solely that of the author credited at the top of this article. GiveMeFootball.com and SportsNewMedia do not take any responsibility for the content of its contributors.