The London Olympic Stadium is one of 13 venues hosting the Rugby Union World Cup in 2015.
Wembley, Twickenham and the Millennium Stadium are also on the list, which contains eight football stadiums.
However, International Rugby Board chairman has played down the significance of that fact, insisting each stadium will become a ‘World Cup venue’ rather than a football ground hosting a different sport.
"The Rugby World Cup is very special. It's not a football stadium or a rugby stadium, it's a stadium for the Rugby World Cup," said IRB chairman Bernard Lapasset.
Rugby Football Union chief executive Ian Ritchie feels the same way, and believes the event can capture a nation’s imagination in both the north and south.
"It is truly a national event that the game and the country will feel a part of," he said.
Debbie Jevans, chief executive for England Rugby 2015, feels the same way, and is confident the event will provide affordable access for all people.
"It is a great mix and will ensure that 92% of the population is within 50 miles of a World Cup venue,” she’s quoted as saying by the BBC.
"We're confident we're going to be able to honour the minimum access prices that there were and that's certainly a commitment to us to be able to do that. We really wanted to take England to the north west and we are delighted Manchester City came to the table.
"We want 2015 to remembered as a rugby year, the Rugby World Cup, and to create a generation of rugby heroes and role models."
Old Trafford had originally been penciled in as a venue, but was removed in the final stages ahead of today’s much-anticipated announcement.
The Etihad Stadium, home of Manchester City, will host one of England’s Pool A games, with the red rose playing their other three matches at Twickenham.
Exeter’s Sandy Park is the smallest venue on the list, with a maximum capacity of 12,300 people. It’s one of only two other rugby-specific stadiums on the final list, with Gloucester’s Kingsholm also making the cut with a capacity of 16,115.
2015 Rugby Union World Cup venues:
Twickenham - 81,605 (London)
Wembley - 90,256 (London)
Olympic Stadium - 54,000 (London)
Millennium Stadium - 74,154 (Cardiff)
Etihad Stadium - 47,800 (Manchester)
St James' Park - 52,409 (Newcastle)
Elland Road - 37,914 (Leeds)
King Power Stadium - 32,312 (Leicester)
Villa Park - 42,785 (Birmingham)
Kingsholm - 16,115 (Gloucester)
Stadium MK - 30,717 (Milton Keynes)
Amex Stadium - 30,750 (Brighton)
Sandy Park - 12,300 (Exeter)