Leeds Rhinos, runners-up for the last three years, are the biggest casualties following this weekend’s round of Tetley’s Challenge Cup fifth round fixtures.
The Super League champions lost 24-8 at the John Smith’s Stadium, with winger Leroy Cudjoe crossing the whitewash twice for the hosts.
Wigan Warriors had no such problems in their clash at Hull KR, with Sam Tomkins running in four tries for the competition favourites at Craven Park in an emphatic 46-14 win.
Brian Noble was shown the extent of his task at Salford City Reds, with his side put to the sword at the Halliwell Jones Stadium.
Veteran Australian Brett Hodgson kicked seven goals and scored a try of his own in the 52-6 mauling, whilst Michael Monaghan and Stefan Ratchford scored two tries apiece.
The win of the round went to Catalan Dragons, who smashed Championship York 92-8 in the Stade Gilbert Brutus on Sunday.
Thomas Bosc was instrumental with a try and nine conversions, whilst Kevin Larroyer (4) and Morgan Escare (3) did the most damage from open play in France.
Sheffield are the last remaining second-tier team in the competition, as they beat lower-league rivals Halifax at the Don Valley Stadium.
London Broncos, Hull and the Widnes Vikings complete the list of teams in the last eight, although the RFL are yet to confirm details for the quarter-final draw.