The former Blues boss is tipping his old club to set the standard in England's top-flight in 2013/14, a belief borne out of the probable return of Mourinho, who is set to quit Real Madrid this summer.
Villas-Boas knows his fellow Portuguese tactician well, having worked under him at Porto and Chelsea, and is confident "the Special One" will reinvigorate the Stamford Bridge squad and orchestrate a charge towards the domestic title.
"Chelsea next season will be absolutely the team to beat, bearing in mind the manager change and the manager we expect to come," the Spurs boss told talkSPORT.
Tottenham have also been tipped to mount an assault on the Premier League crown, but Villas-Boas played down suggestions, reiterating that the north London club's primary goal is to finish in the top four and secure Champions League qualification.
"Our step at the moment is to be into the Champions League, not title contenders, but we hope to be competitive next season if we manage to do things properly in the summer," he added.
Tottenham's chances of a top four finish this year hang in the balance going into the final day of the season on Sunday, with victory over Sunderland at White Hart Lane needed in addition to Arsenal failing to beat Newcastle United.
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