The 27-year-old central midfielder has been a key cog in a Juventus team that's won back to back Serie 'A' titles. Manchester United have been linked for the past 12 months, with a £25m bid reportedly mooted at Old Trafford.
Up to now it's seemed unlikely Juventus would ever want to sell one of their key players, but it could be a summer of upheaval in Turin. And that may cast doubt on the future of Marchisio.
Reports in Italy claim that Antonio Conte will renew his contract on the condition that the club's board provide him with a sizeable transfer kitty for the summer.
The Italian champions are thought to be targeting a big-name striker - Carlos Tevez is the latest name to be linked - but a pricey move for top-tier talent could make Marchisio expendable at the right price.
United have not followed up their interest with a formal offer as yet, but they're believed to be on the lookout for a long-term replacement for Scholes.
The 38-year-old has played his last game for United after announcing his decision to retire at the end of the season.
Marchisio, a full Italy international, has scored six goals in 29 Serie 'A' appearances this term. And his contract does not expire until the end of the 2015/16 campaign.