Rafael Nadal and Novak Djokovic are on course to meet in the French Open semi-finals after they were drawn in the same half of the draw on Friday.
The world number one and reigning Roland Garros champion look set to meet a round earlier that in 2012, where Nadal triumphed for the seventh time in Paris.
Andy Murray’s withdrawal through injury meant that Nadal was seeded third behind Djokovic and Roger Federer.
Nadal only returned from a long-term injury lay off in February but he has been in ominous form for his competitors, reaching the final in all eight of the tournaments he has entered and winning six.
Despite such a significant period out and losing to Djokovic on clay in Monte Carlo, Nadal is still the bookies heavy favourite.
Federer, seeded at number two, looks set up to face David Ferrer in the semi-finals, but will fancy his chances of claiming a second title with one of the other top three seeds to be dumped out before the final.
Serena Williams is heavy favourite to take the Women’s singles title after winning four straight title going into the tournament and she will start off against world number 83 Anna Tatishvili.
The world number one will be looking to avoid a repeat of last year’s first round exit at the hands of Virginie Razzano – her only ever Grand Slam first round defeat – as she looks to claim only her second French Open title.
Number two seed Maria Sharapova starts her defence of the title against Su-Wei Hsieh of Taiwan.
Britain’s Laura Robson was handed a tough opener against number ten seed and former world number one Caroline Wozniacki, though the Dane goes into the tournament having lost four consecutive matches on clay.