World number one, Mark Selby, has failed to qualify for the Wuxi Classic, the season-opening major, in China.
It is the first time that any players in the top 16 have had to qualify for a major snooker event where all 128 tour players start in the same round as part of a new format.
Selby lost 5-3 to Welshman Andrew Pagett while there was also defeat for former world champion Shaun Murphy.
Murphy lost 5-1 to 25-year-old Alex Davies, who only this month secured his place on the snooker tour.
Elsewhere, Ronnie O'Sullivan has withdrawn from the event citing personal reasons. O'Sullivan won the World Championship in Sheffield last month, despite not playing since the same tournament the previous year.
The qualifiers are taking place in Gloucester before the tournament starts in China on June 17.
Jimmy White sealed his place on the plane with a 5-3 win over Lee Page, while former world champion Mark Williams beat Ross Muir 5-1.
Defending Wuxi Classic champion Ricky Walden is also on his way to China after scraping past Pankaj Advani 5-4 while Ryan Day beat Noppon Saengkham by the same scoreline.
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