Mourinho will look to continue Chelsea's recent policy of snapping up the game's best young players, and van Ginkel - the 2013 Dutch Young Talent of the Year - and Mangala are the top two priorities.
Mangala, a 22-year-old centre-half at Porto, has been identified as the 'next John Terry' by Chelsea scouts and Mourinho is reportedly ready to sanction a £20m bid.
Manchester United have also been linked with Mangala, after Sir Alex Ferguson's brother Martin Ferguson - United's European scout - gave the defender a glowing recommendation.
Mourinho's other target, the £8m-rated van Ginkel, has enjoyed a breakout campaign in the Eredivisie with Vitesse and is currently with the Netherlands under-21s at the European Championships in Israel.
And the 20-year-old midfielder has admitted he's flattered by reports linking him with Stamford Bridge.
Speaking to Ad.nl after the 5-1 demolition of Russia in the under-21 group stages, van Ginkel said: "I'm not thinking about it [Chelsea interest] right now, but I'm really flattered by their interest."
Van Ginkel and Mangala would continue Chelsea's recent record of buying young talent, following last summer's triple swoop for Eden Hazard, Oscar and Victor Moses.
Mangala, a full French international, would be expected to contribute more straight away, with van Ginkel likely to be viewed as a longer-term project.
A question mark hangs over the future of David Luiz, with Barcelona thought to be interested, and the report claims Mourinho's interest in the Porto defender could be a contingency plan to cope with the potential loss of the Brazilian.