Manchester United manager David Moyes will face Swansea City at the Liberty Stadium in his first Premier League match as the club's new manager, having succeeded Sir Alex Ferguson at the Old Trafford helm.
Ferguson faced the Swans in his final home game as the Manchester United boss, when the veteran Scot lifted a staggering 13th league title, before presiding over his last match the following weekend at West Brom.
Manchester United endured a difficult encounter in south Wales last season, where they were only able to secure a 1-1 draw, while the game ended in controversy when Ferguson claimed Robin van Persie 'could have been killed' by an errant clearance from Ashley Williams.
Following their visit to the Liberty, Jose Mourinho will bring his Chelsea charges to Old Trafford for an already eagerly-anticipated fixture, while Manchester United travel to Anfield the following weekend - a venue where Moyes has never recorded a victory.
The Manchester derby awaits in late September, following the visit of newly-promoted Crystal Palace, with both clubs parading new managers at the helm following the retirement of Ferguson and sacking of Roberto Mancini respectively.
The Christmas period pits United against against West Ham at Upton Park - always a difficult place to go - before meeting Hull City away on Boxing Day and facing another away fixture, this time against Norwich, only two days later.
New Year's day offers up a potentially mouth-watering clash with Tottenham, who memorably triumphed 3-2 on their last visit to Old Trafford.
Manchester United's end of season run-in features no encounters against last season's top five teams, although Moyes faces a tricky test away at former club Everton four games from the conclusion of the campaign.
The final game of Manchester United's 2013-14 Premier League campaign will be against Southampton at St Mary's but, like last term, the Red Devils will hope to have No.21 wrapped up by then.
Full Manchester United fixture list here.