Sixty-three years on from that fateful night at the Maracana and Brazil are still at unease whenever they find themselves up against Uruguay.
Everything was going according to plan for Brazil, when Friaca scored early in the second half to give Brazil, a well-deserved lead. Even when Juan Alberto Schiaffino equalised, Brazil were still on their way to being crowned world champions - as all they needed was a draw.
But, then, out of nowhere, Alcides Ghiggia scored and silenced 200,000 Brazilians who had come to witness their side being crowned the champions of the world.
Instead, they bore witness to the most traumatising defeat which lingers on, in the minds of each and every Brazilian as the 'Maracanazo' ('Maracana Blow').
The scorer who sank Brazil that day, Ghiggia, once said: "Only three people have ever silenced 200,000 people at the Maracana with a single gesture, Frank Sinatra, Pope John Paul II, and I."
Whilst that was certainly true, Brazil has certainly come a long way from that night in Rio. After that day, Brazil became the Verde-Amarela (Green and Yellow) and the white kit which reminded them of the trauma that they went through was put out, once and for all.
Ever since 1950, it has been nothing but vengeance that has driven Brazil on, every time they come up against la Celeste. Since then, Uruguay have twice beaten Brazil in the final of the Copa America.
In 1983, a highly talented team led by the mercurial Socrates fell to Uruguay 3-1 over two legs and became the greatest Brazil team to have nothing to show for their efforts.
Twelve years later, history repeated itself as 1995 final, which saw a Brazil side containing five members of the World Cup-winning squad lose 5-3 on penalties in Montevideo.
And whilst some might argue that Brazil claimed symbolic revenge by defeating Uruguay in the 1989 Copa America final at the Maracana, the memory of the 1950 match refuses to fade. And that is one that lingers long in the memory of any Brazilian, because that was the day that Brazil was supposed to be crowned the best in the world, but one that is now remembered for all the wrong reasons.
Wednesday's Confederations Cup semi-final in Belo Horizonte will be the 71st match between the South American neighbours. Brazil certainly have had the upper hand in this fixture for quite some time and with a team that has been in fabulous form, many are predicting that Brazil will win this one at a canter.
But Brazil would do well to remember the party pooping nature of this Uruguayan side - and when they finally come up against them, it is sure to bring up a 63-year-old nightmare that haunts the Selecao to this day.
And although ever since 'Maracanazo', Brazil have amassed five World Cups and will start the game against la Celeste as strong favourites, victory would be nothing more than a scant consolation.
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