World giants Brazil and Spain could face each other in what would be one of the most highly-awaited international fixture in current world football affairs.
Hosts Brazil, whose squad is flooded with flair and attacking mentality, will play the winner of the other semi-final between Spain and Italy providing they overcome the threat of Uruguay in their match.
With the potential for a clash with world and European champions Spain, the Verde-Amarela squad will know they have to make as much as they can of any possession awarded to them.
They are sure to find it hard to come by with the tiki-taka style of an international team hoping to complete their collection of major continental and worldwide honours.
The likeliness of Spain reaching the final has been increased by controversial striker Mario Balotelli reportedly returning home due to a thigh strain.
The Italians haven't struggled for goals, but the former Manchester City man has been a trigger of some of their successful attacking moves.
Brazil will have to be wary of Uruguay, whose attacking threat cannot be undermined. With the likes of Edinson Cavani, Luiz Suarez and the experienced Diego Forlan, along with Abel Hernandez, who scored for fun against the amateurs of Tahiti.
Defensive mistakes from David Luiz and Dante could've proven costly against a more clinical side than Italy when Balotelli could have given them the lead.
On Spain's attacking front, their options are looking plentiful and of great quality. Chelsea's Fernando Torres is looking a new player having netted four against Tahiti and scoring a slick header in the final group fixture form close range.
All-time top scorer for his country, David Villa, will always be an option for Vincent del Bosque as they will seek to take any opportunity as the fixtures get trickier.
Roberto Soldado was first choice against Nigeria, having been in good form for Valencia all season.
One can never rule out the underdogs, however. Flashing back to the European championships of 2012, Italy refused to give in to Germany, and their tight defence combined with quick attacking movements handed them a 2-0 victory, albeit their goals coming from the crocked Balotelli.
Uruguay are also not to be ruled out. Their Copa America title in 2011 being their last major piece of silverware, beating Paraguay 3-0 in the final.
The key to being a successful underdog is tactics. Get them right, and you're onto a winner. Tiki-taka can be undone by pure resilience and quality on the ball, as shown by Bayern Munich in this year's Champions League.
Brute strength and the ultimate flare can be combatted, this by determination and patience. A cool-under-pressure manager and capable players are key ingredients for an upset.
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