The London Metro reports how the Primera Division outfit secured the former Club Bruges star to a long-term five-year contract, fuelling speculation that the £6million capture will act as a direct replacement for Negredo, who is poised to leave Andalucia.
Spurs boss Andre Villas-Boas has been credited with an interest in signing the Spain international striker, as he looks to strengthen his attacking options at White Hart Lane before the start of the 2013/14 campaign.
Tottenham face competition from Manchester City, though, as their new manager Manuel Pellegrini is also believed to be monitoring Negredo's situation at the Ramon Sanchez Pizjuan Stadium.
The Chilean coach has already confirmed that he's in the market for a new striker this transfer window, and could step up his interest in luring the 27-year-old to the Etihad Stadium.
Earlier this week, Sevilla president Jose Maria del Nido insisted that the club had received no concrete offers for Negredo's services, but a move to the Premier League might still be on the horizon as Tottenham and City close in on the target.