The Sky Bet Football League kicks off tonight with the two oldest clubs playing at the oldest ground.
Sheffield United take on Notts County at Bramall Lane to celebrate the start of the 125th season of the Football League.
Sheffield United boss David Weir is taking charge of his first competitive fixture following his appointment in June.
Weir, who learnt the trade under David Moyes at Everton, has been busy in the transfer window bringing in six new faces that could all feature in tonight's clash.
Right-back Tony McMahon who is recovering from an ankle injury is rated as 'touch-and-go' by Weir and long-term knee victims Shaun Miller and Diego De Girolamo are ruled out.
The Blades won their first three games of last season, the former Scottish international will be hoping to repeat that form.
Weir has a difficult decision to make before kick-off as to who will lead the line for United with both Chris Porter and Lyle Taylor having impressed during pre-season.
County have also been busy during the summer bringing in striker Danny Haynes after arriving from Charlton Athletic. Keith Curle's other summer recruits are all in contention to start.
The visitors, who reappointed Mick Jones as assistant manager 20 years after he left the club, will also look for inspiration from their start last season after winning the first two games.
If the two games from last season are anything to go by, Sheffield are set to come out on top after a 2-1 home win over County last season.
United finished in 5th place last season and was on track to the Play-off final after a 1-0 home win over Yeovil, only to lose 2-0 away and miss out on a day at Wembley.
The Magpies had a relatively average season finishing mid-table in 12th.
The game is being shown live on Sky Sports 1HD at 7.45pm.
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