The Dutch frontman took just six minutes to get on the scoresheet and help send David Moyes on the way to his first trophy as Manchester United manager.
The 30-year-old forward struck again in the 69th minute with a deflected effort, with the outstretched boot of Wigan's James Perch guiding the ball past the helpless Scott Carson.
With the game as good as over at 2-0, there were few noteworthy incidents during the remainder of the half, as United comfortably saw off their SkyBet Championship opponents.
In truth, Wigan rarely threatened the defending Premier League champions, though Emmerson Boyce perhaps spurned Owen Coyle's sides best chance with a header from an in-swinging free-kick mid-way through the first half.
Other than that, it was one-way traffic as United tested Carson on numerous occasions, with Danny Welbeck, Wilfried Zaha and Van Persie all going close.
Coyle's men rarely got out their opponents half, though new signing James McClean fired a warning shot United's way just before half-time.
With the game at 1-0, McClean broke into the Red Devils' area after Chris Smalling - on for the injured Rafael da Silva in the 16th minute - misjudged the bounce of the ball and allowed McClean to hone in on goal.
However, the Republic of Ireland international fired his effort harmlessly across goal with the onrushing Grant Holt clearly frustrated with his new teammate.
Moyes' side showed their class throughout and saw out the game with ease, getting the new era at Old Trafford off to the best possible start with a trophy - albeit the Community Shield.
Manchester United fans will be hoping this is the first of many under Moyes, whilst Wigan's attentions now turn to Saturday's league clash away to Bournemouth, while United kick-off their season away to Swansea.