Cesc Fabregas has been forced to pull out of Spain's squad for their friendly against Ecuador after spraining his ankle ligaments in a pre-season friendly game with Barcelona.
The midfielder sprained his right ankle during Barcelona's 3-1 victory over Malaysia on Saturday, and was sent for tests after the game.
Having been assessed by doctors it has now been confirmed that the 26-year-old will miss the trip to South America.
A statement on Barcelona's official website read: "Cesc Fabregas had a number of tests this morning after arriving back from Malaysia to measure the extent of the ankle injury he picked up in Saturday’s match.
"It has subsequently been confirmed that the player has sprained a ligament in his right ankle.
"Club doctors have contacted the Spanish FA to recommend that the player should not join the national squad for the friendly against Ecuador so that he can undergo treatment in Barcelona."
Whether Fabregas will be fit for the start of the new La Liga campaign remains unclear but news of his withdrawal will come as a blow to new Barcelona boss Gerardo Martino, who could also be without Lionel Messi who sat out the win on Saturday with a thigh complaint.