Spain national team coach Vicente del Bosque has made several changes to his squad ahead of their friendly against Ecuador on Wednesday.
The squad has nine players missing from the team that had participated in the Confederations Cup in Brazil and includes seven new faces.
Among those new faces called up are five players who featured for the Spanish U21 team in their victorious European Championship campaign in Turkey this summer.
Inigo Martinez, Koke Resurreccion and Cristian Tello have been called up to the senior squad for the first time while their teammates Isco Alarcon and Thiago Alcantara complete the quintet.
Inigo was proud of his first call up to the senior national squad and used Twitter to thank his family and friends for their support.
"Thanks a lot to all those who have congratulated me. I want to thank my family, friends, teammates and followers. It's an honour to be in the Spain squad!" he said.
Koke was also delighted to be handed his first call to the senior side. "It's a dream that I didn't expect. I'm delighted to have the opportunity and really appreciate Del Bosque's faith in me. The work with my teammates and my performance in the under-21 tournament has been highly valued by the coaches and I would like to thank them for that."
Tello, meanwhile, said he came to know of his selection through Twitter: "I found out in Twitter. I can't ask for more. I'm at the best club in the world and now I'm going to play for the full Spain team. It is the greatest honour you can aspire to and an incredible opportunity."
The complete list of the squad called up for the friendly against Ecuador:
Goalkeepers: Iker Casillas (Real Madrid), Jose Manuel Reina (Napoli), Victor Valdes (Barcelona)
Defenders: Alvaro Arbeloa (Real Madrid), Sergio Ramos (Real Madrid), Inigo Martinez (Real Sociedad), Raul Albiol (Napoli), Cesar Azpilicueta (Chelsea), Jordi Alba (Barcelona)
Midfielders: Javier Martínez (Bayern Munich), Thiago Alcantara (Bayern Munich), Koke Resurreccion (Atletico de Madrid), Cesc Fabregas and Andres Iniesta (Barcelona), Francisco Alarcon 'Isco' (Real Madrid), Santiago Cazorla (Arsenal), Jesus Navas (Manchester City), David Silva (Manchester City)
Forwards: Alvaro Negredo (Manchester City), Fernando Llorente (Juventus), Cristian Tello (Barcelona)
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