Arsenal duo Santi Cazorla and Mikel Arteta are both injury concerns for the Gunners' season opener against Aston Villa this weekend.
Cazorla, who will return to north London on Thursday night, was on the scoresheet for Spain as they beat Ecuador yesterday evening, however he will be assessed once he is back in England.
Arteta is currently struggling with a thigh problem and could also miss the game at the Emirates on Saturday.
These latest concerns come after Theo Walcott was taken off with a swollen knee in England's 3-2 victory over Scotland, with Aaron Ramsey and Bacary Sagna also picking up ankle injuries while on international duty.
On the injury front, Arsenal boss Arsene Wenger told reporters: "We have positive news from the players on international duty. All the texts we have had back are okay.
"The games were quite intense, but we hope everyone comes back in good shape.
"Cazorla played almost a full game. He only lands in London tonight (Thursday), so we will see how he is tomorrow.
"Mikel has a slight thigh problem. We have to check that. I don't know if he will be out for the weekend. He has a scan today."
Nacho Monreal and Thomas Vermaelen are already confirmed absentees for the Gunners' match against Villa and Wenger stated the club-captain will still be out for a while.
"It is a while longer for him," said Wenger. "It is difficult to put a timescale on it, but it will be a bit longer. He is progressing okay."
And with only Yaya Sanogo signed so far this summer, Wenger's side could be extremely depleted for the start of the campaign.