Arsene Wenger has been dealt a major blow ahead of the new season, with midfielder Mikel Arteta being ruled out for six weeks after sustaining a torn quadricep muscle.
The Frenchman revealed that his vice-captain underwent a scan after picking up the injury during training on Thursday.
Initial thoughts were that it was a slight strain, which would only rule him out for a couple of days, but the results later indicated a tear - meaning the Spaniard will miss over a month of action.
Arteta is set to miss vital fixtures including the Champions League qualifiers against Fenerbahce and the north London derby against Tottenham.
The latest injury problems at Arsenal will concern Wenger who is already without Thomas Vermaelen, Nacho Monreal and Abou Diaby, with Bacary Sagna facing a race against time to prove his fitness.
Arsenal fans will now be hoping that the manager increases his efforts to bring in new recruits after being left frustrated by missing out on big-name signings including Luis Gustavo, Gonzalo Higuain and potentially Luis Suarez.
Wenger had boasted about having £100million to spend in this summer's transfer window but the Gunners have yet to stamp their authority.
However, there is better news for Arsenal fans regarding Aaron Ramsay. After pulling out of the Wales squad for the friendly against the Republic of Ireland earlier this week, he is expected to line up against Aston Villa for the season opening fixture.
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