Arsenal have been dealt a fresh blow with Mikel Arteta reportedly being ruled out for up to six weeks, so who will make Arsene Wenger's first-team squad on Saturday?
Arteta's fellow countryman, Santi Cazorla is also a doubt after making a 10,000 mile round-trip to Ecuador and back, and having arrived back in England on Thursday, will be assessed for the match, though a spot on the bench looks more likely than a start for now.
Jack Wilshere returned to the fold having played 45 minutes for England, though has not looked fully match-fit so far, with Aaron Ramsey missing Wales' game against the Republic of Ireland through a minor ankle injury, though it is reported that he may be fit to face Villa.
Yaya Sanogo was withdrawn from the France U21 squad, with Bacary Sagna hobbling off for the senior squad it looks unlikely that either will take part.
The mass of departures has not helped the squad's depth, and Wenger will surely be looking to add to his squad before the deadline, with names such as Suarez and Gustavo constantly linked.
Monreal, Vermaelen, Arteta, Diaby and Miyaichi have all been ruled out of the game, and with Ramsey, Sanogo, Wilshere and Sagna looking doubtful, here are the likely potential candidates for the game:
GK: Szczesny, Fabianski
DEF: Mertesacker, Koscielny, Jenkinson, Gibbs, Hayden, Bellerin
MID: Rosicky, Oxlade-Chamberlain, Wilshere, Cazorla, Eisfeld, Zelalem, Frimpong
ATT: Giroud, Podolski, Walcott, Akpom, Park, Bendtner
Write for GiveMeSport! Sign-up to the GMS Writing Academy here: http://gms.to/130seMa
DISCLAIMER: This article has been written by a member of the GiveMeSport Writing Academy and does not represent the views of GiveMeSport.com or SportsNewMedia. The views and opinions expressed are solely that of the author credited at the top of this article. GiveMeSport.com and SportsNewMedia do not take any responsibility for the content of its contributors.