Roberto Soldado's 50th-minute penalty ensured his side sealed the three points against Premier League new-boys Crystal Palace.
Tottenham striker Soldado - who was handed his Premier League debut along with Nacer Chadli and Paulinho - scored just after half-time when he converted a second-half penalty.
The Eagles - who were playing their first game back in the top-flight since the 2004/05 campaign - started the match brightly by constantly pressing their opponents.
Palace's opponents looked particularly strong down the right - with Aaron Lennon and Kyle Walker combining well throughout the opening 45 minutes.
However Andre Villas-Boas' side rarely threatened Eagles goalkeeper Julian Speroni during the opening half.
Tottenham's only real chance before the interval came when Walker played in Lennon - whose shot failed to trouble Speroni.
The north London side started the second half with more intensity and were rewarded for their positivity when Dean Moxey was penalised for handling inside the penalty area.
Soldado - a £26million summer signing from Valencia - dispatched from 12 yards to give his side the lead.
The south London side were unable to break down Tottenham's resolute defence - despite Palace boss Ian Holloway throwing on attacking trio Jonathan Williams, Marouane Chamakh and Kevin Phillips in hope of an equaliser.