Manchester United face Chelsea on Monday night in what will be the first 'big four' clash of the season.
The game will be a tense affair, especially as speculation continues to link Wayne Rooney with a move to Manchester United's title rivals.
The match will be a stern test for former Everton boss David Moyes, who failed to beat any of the top four teams away from Goodison Park while he was at the Toffees.
The Red Devils started their season with an impressive 4-1 win against Swansea City but Moyes will know Jose Mourinho's side will be desperate for the three points.
Chelsea on the other hand, go into the match on the back of two successive Premier League wins - having defeated Hull on the opening day of the season before their slender 2-1 midweek victory against Aston Villa.
Here are the top five potential battles of Monday's games.
Follow Anthony Hay on Twitter
Do YOU want to write for GiveMeSport? Get started today by signing-up and submitting an article HERE: http://gms.to/writeforgms