Historic rivals Liverpool and Manchester United do battle this Sunday with Brendan Rodgers looking to record his first win against United as Liverpool manager.
Likewise, a win at Anfield still eludes David Moyes throughout his career, but he is now at a club who are a level above Everton, and will be hoping his United side can come away victorious.
Still, Sunday's match has all the ingredients for a blockbuster.
Rodgers' men go into Sunday's encounter following two back-to-back 1-0 Premier League victories, while they were also surprisingly pushed to extra-time by Notts County in the Capital One Cup on Tuesday, running out eventual 4-2 winners.
Daniel Sturridge is in supreme form and oozing confidence. He has scored both the winners in Liverpool's two league games, while bagging a brace against Notts County.
Phillipe Coutinho is a player coming increasingly to the fore displaying great balance, vision and weight of passing this season.
Manchester United will feel fairly content with their start to the season which has resulted in four points from two difficult games; away to Swansea and at home to Chelsea.
United were very characteristic in their ruthlessness, professionalism and innate ability to win at Swansea in a game which for large periods they struggled to gain a foothold, but continued to look dangerous on the counter-attack.
Star man Robin van Persie has exemplifies that, despite having a quiet game against Chelsea and club captain Nemanja Vidic has been an imperious rock at the back for United.
Liverpool's and United's objectives are at different ends of the spectrum, with Liverpool looking to regain a place in Europe's elite competition for the first time in four years, and David Moyes looking to maintain the Premier League dominance that United have been so accustomed to over the last two years and retain the title.
Still, despite different goals for both sides, it has no bearing on this derby.
Liverpool will be looking to expose the transition United have and are still currently going through, by compounding even more pressure onto one of the most pressurised jobs in world football with a win.
Moyes, in the meantime, will want to prove he has the capabilities to manage at the highest level by sending out a message.
I can envisage a great spectacle of goals, controversy and passion.
Making things all the more interesting is the fact that players such as Kolo Toure, Sebastian Coates, Aly Cissoko, Joe Allen along with Luis Suarez are not in contention for Liverpool due to injuries and suspensions.
Rafael da Silva, Luis Nani, Darren Fletcher and Javier Hernandez are not expected to be able to play a part for United either.
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