Minus a ton of receiving options and with Steven Ridley having a terrible day, it was down to Tom Brady to carry the New England Patriots to a win over the Buffalo Bills.
Minus nearly every receiving option he had last year, Brady looked towards one of the few left as he found Julian Edelman for two touchdowns.
Brady also hooked up with Danny Amendola for 10 catches and 104 yards and although he targeted Kenbrell Thompkins 14 times, the rookie only managed to snag four catches in the game.
For the Bills, EJ Manuel looked impressive in his debut but their running game faltered, especially CJ Spiller who finished with 14 yards a fumble.
Geno Smith's first game for the New York Jets came right down to wire as they squeaked past the Tampa Bay Buccaneers 17-16.
After Rian Lindell's field goal gave the Bucs a two point lead with 0:34 to play, it looked over. Geno Smith had other plans though. A 25-yard pass over the middle to Kellen Winslow and then a 10-yard run, followed by a late-hit penalty on Lavonte David, put the Jets in range for a game-winning field goal.
Nick Foles duly dispatched the kick, a 48-yard attempt as the Jets started the season 1-0.
Every team in the AFC North started with a loss this year after the Pittsburgh Steelers, Cincinnati Bengals, Baltimore Ravens and Cleveland Browns all lost.
Pittsburgh struggled to get anything going against the Tennessee Titans and lost 16-9. They had taken the lead with a bizarre safety when Titans returner Darius Reynaud backed into his own endzone on the kickoff, not realising he had done so and subsequently knelt down for what he thought was a touchback.
However, a stout defence and gradually moving offence was enough for the Titans, as Jackie Battle's three-yard TD was followed by three Rob Bironas field goals.
Elsewhere, the Bengals fell to the Chicago Bears in a close contest. Brandon Marshall's 19-yard TD in the fourth quarter saw off the Bengals, despite AJ Green's 162-yard, 2 TD performance.
The defending Superbowl champions, the Baltimore Ravens, were stomped by the Peyton Manning-led Denver Broncos 49-27 as Manning threw for seven touchdowns - two each to Wes Welker, Julias Thomas and Demaryius Thomas.
Finally, the Cleveland Browns couldn't find a way to get anything but Jordan Cameron going on offence as they fell 23-10 to the Miami Dolphins.
Cameron had 108 yards and a touchdown but nobody else came close to 50 yards receiving or rushing on the Browns offence meaning that a 34-yard Brian Hartline TD catch and Daniel Thomas 1-yard TD run was enough to put the Browns away.
The Indianapolis Colts and Tennessee Titans stand atop of the AFC South. As mentioned above, the Titans saw off the Pittsburgh Steelers, while the Colts survived a late scare from the Terrelle Pryor-led Oakland Raiders.
In his first start for the Raiders, Pryor didn't look too effective throwing the ball but at the end of the day he led the NFL for rushing yards as he ran for 112 yards.
His running put the Raiders in position for a 5 yard-TD as Pryor connected with Denarius Moore to take the lead. But it wasn't to be, however, as Andrew Luck saw the game out with some fine running of his own. The former no.1 draft pick scrambled 19 yards into the endzone to carry his team through to win 21-17.
The Jacksonville Jaguars slumped to an embarrassing 28-2 loss to the Kansas City Chiefs.
A fine special teams play gave the Jags the lead early in the first quarter, as they blocked a punt for a safety, but from there out it was all the Chiefs with Alex Smith throwing for two TDs in his first game for the Chiefs.
A short Jamaal Charles run and Tamba Hali's 10-yard interception return capped the game off for the Chiefs.
The Houston Texans rallied back from 21 points down to comeback and defeat the San Diego Chargers on Monday night.
The comeback included a 17-point fourth quarter, with the Texans winning the game with a 41-yard Randy Bullock field goal as time expired.
The Broncos and Chiefs top the division after their aforementioned wins, while the Raiders start 0-1 after their loss to the Colts.
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