In Arsene Wenger's press conference on Thursday, the Arsenal boss confirmed that Tomas Rosicky will not make the squad for the Gunners' trip to Sunderland on Saturday.
Aaron Ramsey and Jack Wilshere are in contention, while record signing Mesut Özil could make his debut from the start against Paolo Di Canio's struggling Black Cats.
Mikel Arteta, Lukas Podolski and Alex Oxlade-Chamberlain will not be fit in time for Arsenal's trip to the North-East, while long-term absentee and club captain Thomas Vermaelen may be ready for selection in time for Stoke City the following Sunday.
Arsenal are boosted by the summer signings of Emiliano Viviano and Mathieu Flamini, along with club-record signing Mesut Özil.
Arsene Wenger confirmed in his pre-match press conference that the German international will make his debut for Arsenal this weekend, though whether he will start or come on from the bench remains to be seen.
Theo Walcott and Jack Wilshere will again be available for selection after both being substituted for England following injury scares, while French under-21 international Yaya Sanogo's absence means Arsenal may be forced to turn to Nicklas Bendtner to play understudy to France striker Olivier Giroud.
Abou Diaby is on the long-term injury list.
Arsene Wenger may choose to stick with the experience and defensive nous of Mathieu Flamini at the base of midfield after his solid performance against Tottenham in the last round of Premier League fixtures.
Wilshere and Özil could join Flamini in the midfield, with Cazorla on the left and Walcott to the right. The Gunners' only recognised striker Giroud will spearhead the attack.
In defence, there are no further injuries or suspensions and, with Bacary Sagna returning to fitness, may start ahead of Carl Jenkinson. The Gunners' back-four may also include Kieran Gibbs, Laurent Koscielny and Per Mertesacker.
Wojciech Szczesney is expected to start in goal, while Emiliano Viviano could take Lukasz Fabianski's place on the bench.
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