The 21-year-old attacking midfielder was brought in from Roma and made his Tottenham debut as a substitute against Arsenal in the 1-0 north London derby defeat.
But Villas-Boas has warned Spurs fans not to expect too much too soon from the Argentine, as struggles with the language could lead to struggles on the pitch.
"He's going to suffer problems of adaptation because he doesn't speak a word of English," said Villas-Boas.
"He has to adapt to a completely different culture and mentality, which we are sure he will, but we're unsure of how much time it will take, but he will.
"I think the qualities he brings are his creativeness, his ability to find the last pass that leads to a goal. He's a natural talent. He's not a pure, pure winger; he's creative and likes to come inside and find different spaces. He's a player with tremendous potential that we have to work on.
"He's a wonderful, gifted footballer. The fact he's yet to train with the team puts him in a very difficult position to start the game, but it is not impossible.
"For somebody so gifted, adapting shouldn't be a problem."
The new Spurs attacker didn't train today but Villas-Boas said he expects him to be involved in this weekend's match against Norwich on Saturday.
Lamela, who has three caps for Argentina, is expected to fill the role vacated by Real Madrid's Gareth Bale.
The left-footed winger primarily plays from the right, but can feature anywhere across the front line, including as a second striker.
Christian Eriksen is also expected to make his debut for Tottenham against the Canaries following his signing from Ajax.