David Silva is likely to miss the start of Manchester City's European campaign because of a thigh strain.
The Spanish playmaker returned early from international duty for treatment and has been ruled out of his side's Premier League clash with Stoke City this Saturday by manger Manuel Pellegrini.
The 27-year-old is likely to be ready only for next weekend's Manchester derby meaning he will not be available to face Czech side Viktoria Plzen in Europe on Tuesday.
"We will see next week what happened with him," said Pellegrini.
"We hope he can be, not sure - we will try for the derby."
Also missing out against Stoke will be City captain Vincent Kompany, who has been out of action since getting injured against Newcastle in the season-opener.
"Kompany is okay but I think it is a big risk for him to play three matches in one week," Pellegrini added.
"He needs two or three more days to be 100 per cent."
Additional worries for the new boss at the Etihad include Micah Richards who is still out following a hamstring injury and left back Gael Clichy is alos carrying a knock which will rule him out of this weekend's match.
The Sky Blues have won two and lost one - to Cardiff City - so far this season and will be in for a tough game at the Britannia where they have never claimed a Premier League victory.
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